Endocrine hormones acting on kidneys

       ENDOCRINE  HORMONES                 ACTING  ON  KIDNEY             

1.Aldosterone:

★Effects on kidney:

-during hypovolumia/hypotension:Aldosterone  stimulates Na-k pump which ⬆️Na+ reabsorption from DCT(distal collecting tubules), CT(collecting tubules), CD(collecting duct)of renal tubules ➕ also ⬆️CL- and H2O reabsorption along with Na+                         ⬇️

                   ↑ECF volume

                                   ⬇️ 

                  ↑Blood pressure 

-During Hyperkalemia:Aldosterone stimulates Na-k pump which ⬆️K+ excretion into CD(collecting duct) which ⬇️potassium level in the blood..

-During Acidosis :Aldosterone stimulates proton pump which ⬆️proton excretion in CD(collecting duct) by producing acidic urine as a result blood ph comes to normal.. 

Function of Aldosterone 

★Others effects of Aldosterone :

It also ⬆️reabsorption of Na+ & Cl- from sweat & salivary glands and the intestines(especially the colon) also  ⬆️secretion of k+ from sweat and salivary glands..

2.ADH(Antidiuretic hormone):

★Hypovolaemia/hypotension:   

Stimulates ADH release from posterior pituitary gland>> ⬆Water reabsorption from DCT and CD by making them permeable to H2O via cAMP & via V2 receptor >>produce concentrated urine >>increase blood volume>>blood volume and pressure becomes normal.

★Hypotension:

ADH ⬆️ intracellular Ca+ of vascular smooth muscle via V1A receptor by activating  phospholipase C >> which causes contraction of vascular smooth muscle >> causes vasoconstriction >> ⬆️Blood pressure.

Function of ADH

3.ANP:

★It produce by atrium in volume overload

-⬇️NaCl,H2O reabsorption from CD ➕ causes vasodilation & ↑GFR by dilatation of afferent arteriole ➕ ⬇️reninangiotensin-aldosterone system>>>>>>>>>>>>net effect is Natriuresis and Diuresis(salt and water excretion⬆️) 

4.Angiotensin ll:

A powerful Na+ retaining hormone & powerful vasoconstrictor.

★During hypovolaemia Angiotensin ll causes

 ⬆️NaCl,H2O,HCO3 reabsorption from PCT mainly

-⬆️Aldosterone secretion 

-⬆️ADH secretion & stimulates thirst center

-⬇️sensitivity of brain baro-reflex

-it causes constriction of efferent arteriole at physiological concentration to ⬆️GFR,but at high concentration it causes constriction of both afferent and efferent arterioles to reduce RBF &GFR.

          Function of Angiotensin ll

5.Dopamine:

-⬆️RBF &⬇️NaCl reabsorption from PCT >> causes Natriuresis & Diuresis.

6.Parathyroid Hormone:

-⬆️Calcium reabsorption from DCT.

-⬇️Phosphate reabsorption from PCT.

7.Prostaglandin,e.g.PG E2

★Antagonizes sympathetic nervous system activity, ADH,&Angiotensin2 >> causes renal vasodilation,natriuresis,diuresis.

8.Catecholamine:

-renal vasoconstriction >⬇️GFR   -stimulation of RAAS & ⬆️renin secretion   -NaCl reabsorption from PCT & ALH 

Okay now let's know these all together in one slide easily!!!!!